DEPARTMENT OF PHARMACEUTICAL CHEMISTRY

Pharmaceutical chemistry is interdisciplinary science that deals with the phytochemical isolations and characterizations of isolated phytoconstituents. Modern approaches like quantitative structure activity relationship, computer aided novel drug designing and molecular modeling, microwave synthetic chemistry, identification and characterization of novel synthesized compounds or drug using various spectroscopic techniques, development and analysis of New Chemical Entity (NCE). This study helps to understand mechanism of action of drug at molecular level. Modern techniques like High performance liquid chromatography, UV spectroscopy, Infrared spectroscopy, autoanalyser etc. are used to study the chemical nature of drugs. The students are well known with the application of modern scientific technologies in drug development safety and efficacy studies. The department is well equipped with an instrumentation laboratory in which necessary sophisticated instruments like FTIR with ATR technique, HPLC, UV spectroscopy, autoanalyser and various instruments are available to provide facilities to our students, academicians, researchers, technologists to carry out experiments on sophisticated instruments not available in their own institutions. We have well qualified and experienced staff working in different areas like phyto chemistry, computer aided drug design and molecular modelling, synthetic chemistry and HPLC/ UV analytical method development etc. There are well equipped laboratories for undergraduate students and research labs for postgraduate students. Well qualified and experienced staff is the highlight of this department

Vision

The Pharmaceutical chemistry department aims to develop highly qualified competent professional students those are skillful pharmacist with a wide scientific background which will be beneficial for the development of the community

Objective

To provide the needs of students, academicians, researchers, technologists, educational institutions and industries in the surrounding for sophisticated instruments at our institute, with a broad objective to update students & researches about advances in instrumentation.

  • To carry out the analysis of samples received from researchers working in various educational and research institutions, industries and laboratories etc.
  • To carry out the analysis of samples received from researchers working in various educational and research institutions, industries and laboratories etc.
  • To provide facilities to academicians, researchers, technologists to carry out experiments on sophisticated instruments not available in their own institutions.
  • To organize short term workshops and training on the use and application of various instruments for the benefit of research scholars, teachers and personnel from other laboratories and institutions.
  • To train the scholars about latest sophisticated instruments available in research field.
  • To maintain and upgrade the instruments.
  • To promote institutions and industry collaboration through essential services for research and consultancy.

Facilities


FTIR (Cary 630 FTIR)

  • Universal sample holder for analysis using ATR technique
  • ATR with diamond tip for analysis of powders, liquids and thin films using specular reflectance
  • Demountable liquid cell for analysis of samples in liquid form.
  • Magnetic film holder for analysis of thin films.
  • Comparative and overlay study in qualitative analysis.
  • Applicable for transmittance vs. wave number study and absorbance vs. wavelength study.


UV/VIS (UV 1800 SHIMADZU)

  • Wavelength range from180 to 800 nm.
  • Data acquisition in absorbance, transmittance, reflectance and energy modes.
  • Scanning at ultraviolet (180 to 400 nm) and visible region (400-800 nm).
  • Liquid sample analysis using demountable cuvetts.
  • Multi component analysis.
  • Simultaneous estimation of two or more drugs in single method.
  • Comparative and Overlay Spectra for qualitative Analysis.
  • Method Development and Validation as per ICH Guidelines.


HPLC (Agilent Technologies 1260 Infinity II)

  • Applicable to normal phase and reverse phase analysis.
  • Can be operated as gradient as well as isocratic Mode.
  • HLPC pump capable for methods having flow in range 0.2-5 ml/min.
  • Uniform sample injector system operated at 20 µl.
  • Assembled with UV as well as PDA Detector capable to single wavelength and wavelength in range.
  • HPLC method development, validation and stability study as per ICH Guideline.
  • Impurity profile, enantiomeric study.


Auto Analyzer (Micro Lab): Biochemical analysis of sample

Optimum utilization of Instrumentation laboratory

The main focus of department has to be ‘Research & Development programmers’. Research scholars from this institute are always free to access the instrument available. Students of PG courses can utilize the instruments/ equipments and infrastructure generated under instrumentation laboratory at regular interval at different levels of their course/program. Further institute is planning to increase the utility and facility at instrumentation laboratory.

Research Interest

Phytochemistry and establishment of reference standards, computer aided drug design and molecular modelling and QSAR study, Synthesis of different derivatives of drugs and HPLC/UV analytical method development and validation of different drugs etc.



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