Department of Pharmaceutical Chemistry and Qaulity Assurance
Pharmaceutical chemistry is interdisciplinary science that deals with the phytochemical isolations and characterizations of isolated phytoconstituents. Modern approaches like quantitative structure activity relationship, computer aided novel drug designing and molecular modeling, microwave synthetic chemistry, identification and characterization of novel synthesized compounds or drug using various spectroscopic techniques, development and analysis of New Chemical Entity (NCE). This study helps to understand mechanism of action of drug at molecular level. Modern techniques like High performance liquid chromatography, UV spectroscopy, Infrared spectroscopy, autoanalyser etc. are used to study the chemical nature of drugs. The students are well known with the application of modern scientific technologies in drug development safety and efficacy studies. The department is well equipped with an instrumentation laboratory in which necessary sophisticated instruments like FTIR with ATR technique, HPLC, UV spectroscopy, autoanalyser and various instruments are available to provide facilities to our students, academicians, researchers, technologists to carry out experiments on sophisticated instruments not available in their own institutions.
Department of Pharmaceutical Chemistry
Pharmaceutical chemistry is interdisciplinary science that deals with the phytochemical isolations and characterizations of isolated phytoconstituents. Modern approaches like quantitative structure activity relationship, computer aided novel drug designing and molecular modeling, microwave synthetic chemistry, identification and characterization of novel synthesized compounds or drug using various spectroscopic techniques, development and analysis of New Chemical Entity (NCE). This study helps to understand mechanism of action of drug at molecular level. Modern techniques like High performance liquid chromatography, UV spectroscopy, Infrared spectroscopy, autoanalyser etc. are used to study the chemical nature of drugs. The students are well known with the application of modern scientific technologies in drug development safety and efficacy studies. The department is well equipped with an instrumentation laboratory in which necessary sophisticated instruments like FTIR with ATR technique, HPLC, UV spectroscopy, autoanalyser and various instruments are available to provide facilities to our students, academicians, researchers, technologists to carry out experiments on sophisticated instruments not available in their own institutions. We have well qualified and experienced staff working in different areas like phyto chemistry, computer aided drug design and molecular modelling, synthetic chemistry and HPLC/ UV analytical method development etc. There are well equipped laboratories for undergraduate students and research labs for postgraduate students. Well qualified and experienced staff is the highlight of this department
Vision
The Pharmaceutical chemistry department aims to develop highly qualified competent professional students those are skillful pharmacist with a wide scientific background which will be beneficial for the development of the community
Objective
To provide the needs of students, academicians, researchers, technologists, educational institutions and industries in the surrounding for sophisticated instruments at our institute, with a broad objective to update students & researches about advances in instrumentation.
- To carry out the analysis of samples received from researchers working in various educational and research institutions, industries and laboratories etc.
- To carry out the analysis of samples received from researchers working in various educational and research institutions, industries and laboratories etc.
- To provide facilities to academicians, researchers, technologists to carry out experiments on sophisticated instruments not available in their own institutions.
- To organize short term workshops and training on the use and application of various instruments for the benefit of research scholars, teachers and personnel from other laboratories and institutions.
- To train the scholars about latest sophisticated instruments available in research field.
- To maintain and upgrade the instruments.
- To promote institutions and industry collaboration through essential services for research and consultancy.
Facilities
FTIR (Cary 630 FTIR)
- Universal sample holder for analysis using ATR technique
- ATR with diamond tip for analysis of powders, liquids and thin films using specular reflectance
- Demountable liquid cell for analysis of samples in liquid form.
- Magnetic film holder for analysis of thin films.
- Comparative and overlay study in qualitative analysis.
- Applicable for transmittance vs. wave number study and absorbance vs. wavelength study.
UV/VIS (UV 1800 SHIMADZU)
- Wavelength range from180 to 800 nm.
- Data acquisition in absorbance, transmittance, reflectance and energy modes.
- Scanning at ultraviolet (180 to 400 nm) and visible region (400-800 nm).
- Liquid sample analysis using demountable cuvetts.
- Multi component analysis.
- Simultaneous estimation of two or more drugs in single method.
- Comparative and Overlay Spectra for qualitative Analysis.
- Method Development and Validation as per ICH Guidelines.
HPLC (Agilent Technologies 1260 Infinity II)
- Applicable to normal phase and reverse phase analysis.
- Can be operated as gradient as well as isocratic Mode.
- HLPC pump capable for methods having flow in range 0.2-5 ml/min.
- Uniform sample injector system operated at 20 µl.
- Assembled with UV as well as PDA Detector capable to single wavelength and wavelength in range.
- HPLC method development, validation and stability study as per ICH Guideline.
- Impurity profile, enantiomeric study.
FTIR (Cary 630 FTIR)
- Universal sample holder for analysis using ATR technique
- ATR with diamond tip for analysis of powders, liquids and thin films using specular reflectance
- Demountable liquid cell for analysis of samples in liquid form.
- Magnetic film holder for analysis of thin films.
- Comparative and overlay study in qualitative analysis.
- Applicable for transmittance vs. wave number study and absorbance vs. wavelength study.
UV/VIS (UV 1800 SHIMADZU)
- Wavelength range from180 to 800 nm.
- Data acquisition in absorbance, transmittance, reflectance and energy modes.
- Scanning at ultraviolet (180 to 400 nm) and visible region (400-800 nm).
- Liquid sample analysis using demountable cuvetts.
- Multi component analysis.
- Simultaneous estimation of two or more drugs in single method.
- Comparative and Overlay Spectra for qualitative Analysis.
- Method Development and Validation as per ICH Guidelines.
HPLC (Agilent Technologies 1260 Infinity II)
- Applicable to normal phase and reverse phase analysis.
- Can be operated as gradient as well as isocratic Mode.
- HLPC pump capable for methods having flow in range 0.2-5 ml/min.
- Uniform sample injector system operated at 20 µl.
- Assembled with UV as well as PDA Detector capable to single wavelength and wavelength in range.
- HPLC method development, validation and stability study as per ICH Guideline.
- Impurity profile, enantiomeric study.
Auto Analyzer (Micro Lab): Biochemical analysis of sample
Optimum utilization of Instrumentation laboratory
The main focus of department has to be ‘Research & Development programmers’. Research scholars from this institute are always free to access the instrument available. Students of PG courses can utilize the instruments/ equipments and infrastructure generated under instrumentation laboratory at regular interval at different levels of their course/program. Further institute is planning to increase the utility and facility at instrumentation laboratory.
Research Interest
Phytochemistry and establishment of reference standards, computer aided drug design and molecular modelling and QSAR study, Synthesis of different derivatives of drugs and HPLC/UV analytical method development and validation of different drugs etc.
  | Dr.Ashish GawaiM. Pharm., Ph.D. | Professor and Head | Department : Pharmaceutical Chemistry >>View Profile<< |
 | Dr. Dipak LokwaniM. Pharm., Ph.D. |Associate Professor| >>View Profile<< |
  | Ms. Rupalee DhaneM. Pharm.| Assistant Professor | Department: Pharmaceutical Chemistry >>View Profile<< |
 | Mr. Satish ShelkeM. Pharm.| Assistant Professor | Department : Pharmaceutical Chemistry >>View Profile<< |
  | Mr. Rushikesh DiwareM. Pharm.| Assistant Professor | Department: Pharmaceutical Chemistry >>View Profile<< |
  | Mrs. Snehal DeshmaneM. Pharm. |Assistant Professor| >>View Profile<< |
 | Miss Dipali TapreM. Pharm. |Assistant Professor| >>View Profile<< |
  | Miss. Nisha GadiyaM. Pharm., | Assistant Professor| >>View Profile<< |
| Dr. Sunil GuptaM. Pharm, Ph.D. | Professor | Department: Pharmaceutical Chemistry >>View Profile<< |
PUBLICATIONS
Sr No. | Name of Author | Title of Research Work | Name of Journal | Publication Year | ISSN No | Impact Factor |
1.
| Vijay Borkar , Gajanan Sonwane, Parmeshwar Devhare, Rushikesh Diwre Shirish Jain | Evaluation of anti diabetic activity of Echinochloa Colona plant extract | International Journal of Pharmaceutical Sciences and Research | 2021 | 0975-8232 |
0.2 |
2. | Dr. V. S. Borkar, Mr. Shariq Khan, Dr S. M. Sonwane | Discovery of Naturally Occurring Flavonoids as Human Cytochrome P450 (CYP3A4) Inhibitors with the Aid of Computational Chemistry | Indo Global Journal Of Pharmaceutical Sciences | 2020 | 2249- 1023 | 0.2 |
3. | Borkar VS, Senthil Kumaran K, Senthil Kumar KL, Gangurde, HH, Chordiya MA. | Ethno medicinal properties of Echinochloa colona and Hydrolea zeylanica. A review. | World. J. Pharm. Res | 2016 | 2277– 7105 |
|
4. | Borkar VS, Senthil Kumaran K, Senthil Kumar KL, Gangurde HH, Chordia MA. | Antioxidant effect and characterization of bioactive constituents isolated from Echinochloa colona (Poaceae) | World. J. Pharm. Res. | 2015 | 2277– 7105 |
|
5. | Borkar VS, Senthil Kumaran K, Senthil Kumar KL, Gangurde HH, Chordiya Mayur A. | Antidiabetic activity and isolation of bioactive compounds from Hydrolea zeylanica.;
| Indonesian J. Pharm. | 2015 | 2338-9427 |
|
6.
| Borkar VS., Senthil Kumaran K. Senthil Kumar KL, Gangurde HH, Chordiya MA. | Anti-ulcer effect of fractions of Hydrolea zeylanica on pyloric ligated induced ulcers in rats. | J. Pharm. Sci. Pharmacol. | 2015 | 2333-3715 |
|
7. | Borkar VS, Gangurde HH, Chordiya MA, Baste NS, | Isolation and Evaluation of Vigna Mungo Gum as a Novel Binder. | African Journal of Pharmaceutical Sciences and Pharmacy | 2012 | 2152-7849 |
|
8. | Borkar VS, Gangurde HH, Gulecha VS, , Mahajan MS, Khandare RA, Mundada AS. | Swine Influenza A (H1N1 Virus): A Pandemic Disease | Systematic Reviews in Pharmacy | 2011 | 0975-8453 |
|
9. | Borkar VS, Gangurde HH, Mundada AS, Gulecha VS, Mahajan MS. | Gastroretentive Dosage Forms: An Overview. | Inventi Rapid | 2010 | 09763791 |
|
10. | Borkar VS, Gangurde H.H, Gulecha VS, Bhoyar PK., Mundada AS. | Evaluation of In vitro anthelmintic activity of leaves of Butea monosperma. | International Journal of Phytomedicine
| 2010 | 0975-0185 |
|
11. | Borkar VS, Gangurde H.H, Gulecha VS, Mundada AS, Baheti JR. | Evaluation of In vitro anti-inflammatory activity of leaves of Butea monosperma.
| Indian drugs | 2010 |
|
|
12. | Borkar VS, Mundada AS, Mahajan MS, Gangurde HH. | Formulation and evaluation of polyherbal antipsoriatic cream. | Pharmacologyonline | 2009 | 1827-8620 |
|
13. | Borkar VS, Mundada AS, Bhoyar PK. | Formulation and Evaluation of Taste Masked Sustained Release Dosage Form of Metformin Hydrochloride Using Indion Resin. | Research Journal of Pharma. Dosage Forms and Tech. | 2009 | 0975-234X |
|
15. | Borkar VS, Sawarkar HS, Siddique S, S. Kaurav. | In vitro evaluation of Butea monosperma Lam. for antioxidant activity. | Oriental Journal of Chemistry | 2008 | 0970 – 020X |
|
16. | Ashish M. Dhote , Vikas R. Patil, Deepak K. Lokwani , Nikhil D. Amnerkar , Vinod G. Ugale, Nitin B. Charbe, Bhoomendra A. Bhongade and Saurabh C. Khadsea | Strategic analyses to identify key structural features of antiviral/antimalarial compounds for their binding interactions with 3CLpro, PLpro and RdRp of SARS-CoV-2: in silico molecular docking and dynamic simulation studies | J. Biomol. Struct. Dyn.
| 2021 | 1538-0254 | 3.31 |
17. | Santosh Mokale, Deepak Lokwani,* and Abdul Mujaheed | Pyridine/Pyrimidine Substituted Imidazol-5-one Analogs as HIV-1 RT Inhibitors: Design, Synthesis, Docking and Molecular Dynamic Simulation | Curr HIV Res
| 2021 | 1873-4251 | 1.58 |
18. | Mithun Rudrapal, Abdul Rashid Issahaku, Clement Agoni, Atul R. Bendale, | In silico screening of phytopolyphenolics for the identification of bioactive compounds as novel protease inhibitors effective against SARS-CoV-2 | J. Biomol. Struct. Dyn.
| 2021 | 1538-0254 | 3.31 |
19. | Aniket P. Sarkate*, Vidya S. Dofe, Shailee V. Tiwari, Deepak K. Lokwani*, Kshipra S. Karnik, Darshana D. Kamble, Mujahed H.S.H. Ansari Suneel Dodamani, Sunil S. Jalalpure, Jaiprakash N. Sangshetti, Rajaram Azad, Prasad V.L.S. Burra, Shashikant V. Bhandari | One pot synthesis, in silico study and evaluation of some novel flavonoids as potent topoisomerase II inhibitors | Bioorg. Med. Chem.
| 2021 | 0968-0896 | 2.823 |
20. | Ramakant A. Kardile, Aniket P. Sarkate, Avinash S. Borude, Rajendra S. Mane, | Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: In vitro screening, molecular docking and ADME predictions | Bioorg. Chem.
| 2021 | 0968-0896 | 5.275 |
21. | Deepak K. Lokwani, Aniket P. Sarkate, Kshipra S. Karnik, Anna Pratima G. Nikalje and Julio A. Seijas | Structure-Based Site of Metabolism (SOM) Prediction of Ligand for CYP3A4 Enzyme: Comparison of Glide XP and Induced Fit Docking (IFD) | Molecules
| 2020 | 1420-3049 | 4.411 |
22. | Vidya S. Dofe, Aniket P. Sarkate, Shailee V. Tiwari, Deepak K. Lokwani, Kshipra S. Karnik, | Ultrasound assisted synthesis of tetrazole based pyrazolines and isoxazolines as potent anticancer agents via inhibition of tubulin polymerization | Bioorg. Med. Chem. Lett.
| 2020 | 0960-894X | 2.823 |
| Harun Patel, Iqrar Ahmad, Harsha Jadhav, Rahul Pawara, Deepak Lokwani and Sanjay Surana | Investigating the Impact of Different Acrylamide (Electrophilic Warhead) | Comb. Chem. High Throughput Screen
| 2020 | 1875-5402 | 1.339 |
23. | KS Karnik, AP Sarkate, DK Lokwani, IS Narula, PVLS Burra, PS Wakte | Development of triple mutant T790M/C797S allosteric EGFR inhibitors: a computational approach | J. Biomol. Struct. Dyn.
| 202 | 1538-0254 | 3.31 |
24.
| HM Patel, M Shaikh, I Ahmad, D Lokwani, SJ Surana | BREED based de novo hybridization approach: generating novel T790M/C797S-EGFR tyrosine kinase inhibitors to overcome the problem of mutation and resistance in non-small cell lung cancer (NSCLC) | J. Biomol. Struct. Dyn.
| 2020 | 1538-0254 | 3.31 |
25.
| Nitin M. Thorat, Aniket P. Sarkate, Deepak K. Lokwani, Shailee V. Tiwari, Rajaram Azad & Shankar R. Thopate | N-Benzylation of 6-aminoflavone by reductive amination and efficient access to some novel anticancer agents via topoisomerase II inhibition | Molecular Diversity
| 2020 | 1573-501X | 2.943 |
26. | Saurabh C. Khadse Nikhil D. Amnerkar, Krushna S. Dighole, Ashish M.Dhote, Vikas R.Patil, Deepak K. Lokwani, Vinod G.Ugale, Nitin B.Charbe, Vivekanand A. Chatpalliwar | Hetero-substituted sulfonamido-benzamide hybrids as glucokinase activators: Design, synthesis, molecular docking and in-silico ADME evaluation | J. Mol. Struct.
| 2020 | 0022-2860 | 3.196 |
27. | Rohini N. Shelke, Dattatraya N. Pansare, Aniket P. Sarkate, Ishudeep K. Narula, Deepak K. Lokwani, Shailee V. Tiwari, Rajaram Azad, Shankar R. Thopate | Synthesis and evaluation of novel sulfonamide analogues of 6/7-aminoflavones as anticancer agents via topoisomerase II inhibition | Bioorg. Med. Chem. Lett.
| 2020 | 0960-894X | 2.823 |
28. | Saurabh B. Ganorkara, Yvan Vander Heyden, Atul A. Shirkhedkar, Deepak K. Lokwani, Dinesh M. Dhumal, Preeti S. Bobade | Pharmaceutical analysis combined with in-silico therapeutic andtoxicological profiling on zileuton and its impurities to assist in modern drug discovery | J. Pharma. Biomed. Anal.
| 2020 | 0731-7085 | 3.935 |
29. | Saurabh C. Khadse, Nikhil D. Amnerkar , Manasi U. Dave, Deepak K. Lokwani, Ravindra R. Patil, Vinod G. Ugale, Nitin B. Charbe and Vivekanand A. Chatpalliwar | Quinazolin-4-one derivatives lacking toxicity-producing attributes as glucokinase activators: design, synthesis, molecular docking, and in-silico ADMET prediction. | Future J. Pharma. Sci.
| 2019 | 2314-7253 | 0 |
30. | TR Deshmukh, AP Sarkate, DK Lokwani, SV Tiwari, R Azad, BB Shingate, | New amide linked dimeric 1, 2, 3-triazoles bearing aryloxy scaffolds as a potent antiproliferative agents and EGFR tyrosine kinase phosphorylation inhibitors. | Bioorg. Med. Chem. lett.
| 2019 | 0960-894X | 2.823 |
31. | NS Sakle, D Lokwani, SN Mokale | Caesalpinia pulcherrima arrests cell cycle and triggers reactive oxygen species-induced mitochondrial-mediated apoptosis and necroptosis via modulating estrogen and estrogen receptors. | Pharmacognosy Magazine
| 2019 | 0976-4062 | 1.085 |
32. | Asha V. Chate, Ankita A. Redlawar, Giribala M. Bondle, Aniket P. Sarkate, Shailee V. Tiwari and Deepak K. Lokwani, | A new efficient domino approach for the synthesis of coumarin-pyrazolines as antimicrobial agents targeting bacterial D-alanine-D-alanine ligase. | New J. Chem.
| 2019 | 1369-9261 | 3.591 |
33. | M Bhosle, LD Khillare, JR Mali, A Sarkate, DK Lokwani, SV Tiwari, | DIPEAc promoted one-pot synthesis of dihydropyrido [2, 3-d: 6, 5-d’] dipyrimidinetetraone and pyrimido [4, 5 d] pyrimidine derivatives as potent tyrosinase inhibitors and anticancer agents: in vitro screening, molecular docking and ADMET predictions. | New J. Chem.
| 2018 | 1369-9261 | 3.591 |
34. | Santosh N Mokale*, Nikhil S Sakle, Swati A Bhavale, Deepak K Lokwani, Vishakha Shelke. | Design, Synthesis and Anti-breast Cancer Activity of Some Novel Substituted Isoxazoles as Anti-breast Cancer Agent. | Anti-Cancer Agents in Med. Chem.
| 2018 | 1875-5992 | 2.505 |
35. | Z Zaheer, SI Shaikh, SN Mokale, DK Lokwani, | Synthesis, Biological Evaluation and Computational Study of New Quinoline Hybrids as Antitubercular Agent, | Lett. Drug Des. Discov.
| 2018 | 1570-1808 | 1.15 |
36. | Shailee V. Tiwari, Anna P.G. Nikalje, Deepak K. Lokwani, Aniket P. Sarkate, Kizukala Jamir. | Synthesis, Biological Evaluation, Molecular Docking Study and Acute Oral Toxicity Study of Coupled Imidazole-Pyrimidine Derivatives, | Lett. Drug Des. Discov.
| 2018 | 1570-1808 | 1.15 |
37. | Shailee V. Tiwari, Sumaiya Siddiqui, Julio A. Seijas , M. Pilar Vazquez-Tato, Aniket P. Sarkate, Deepak K. Lokwani and Anna Pratima G. Nikalje, | Microwave-Assisted Facile Synthesis, Anticancer Evaluation and Docking Study of N-((5-(Substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) Benzamide Derivatives | Molecules
| 2017 | 1420-3049 | 4.411 |
38. | Aniket P. Sarkate, Deepak K. Lokwani, Kshipra S. Karnik and Devanand B. Shinde | Novel 2-(nitrooxy)ethyl 2-(4-(substituted phenyl)-2-((substituted phenyl)amino)thiazol-5-yl)acetate as Anti-inflammatory, Analgesic and Nitric Oxide Releasing Agents: Synthesis and Molecular Docking Studies | Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
| 2017 | 1875-614X | 0 |
39. | VS Dofe, AP Sarkate, DK Lokwani, DB Shinde, SH Kathwate, CH Gill | Novel O‐Alkylated Chromones as Antimicrobial Agents: Ultrasound Mediated Synthesis, Molecular Docking and ADME Prediction, | J. Hetero. Chem.
| 2017 | 1943-5193 | 1.484 |
40. | Sameer I. Shaikh, Zahid Zaheer, Santosh N. Mokale, Deepak K. Lokwani | Development of New Pyrazole Hybrids As Antitubercular Agents: Synthesis, Biological Evaluation And Molecular Docking Study | Int. J. Pharm. Pharm. Sci.
| 2017 | 0975-1491 | 0 |
41. | William Doherty, Nikoletta Adler, Andrew Knox, Derek Nolan, Joanna McGouran, Anna Pratima Nikalje, Deepak Lokwani, Aniket Sarkate, and Paul Evans, | Synthesis and Evaluation of 1,2,3-Triazole-Containing Vinyl and Allyl Sulfones as Anti-Trypanosomal Agents, | Eur. J. Org. Chem.
| 2017 | 1434-193X | 2.889 |
42. | Vidya S. Dofe, Aniket P. Sarkate, Deepak K. Lokwani, Santosh H. Kathwate, Charansingh H. Gill | Synthesis, antimicrobial evaluation, and molecular docking studies of novel chromone based 1,2,3-triazoles, | Res Chem Intermed
| 2017 | 1568-5675 | 2.262 |
43. | Shailee V. Tiwari, Julio A. Seijas, M. Pilar Vazquez-Tato, Aniket P. Sarkate, Deepak K. Lokwani and Anna Pratima G. Nikalje, | Ultrasound mediated one-pot, three component synthesis, docking and ADME prediction of novel 5-amino-2-(4-chlorophenyl)-7-substituted phenyl-8,8a-dihydro-7h-(1,3,4)thiadiazolo(3,2-α)pyrimi-dine-6-carbonitrile derivatives as anticancer agents, | Molecules
| 2016 | 1420-3049 | 3.267 |
44. | A.P. Sarkate, P.R. Murumkar, D.K. Lokwani, A.D. Kandhare, D.B. Shinde, K.G. Bothara, | Design of selective TACE inhibitors using molecular docking studies: Synthesis and preliminary evaluation of anti-inflammatory and TACE inhibitory activity, | SAR QSAR Environ Res.
| 2015 | 1029-046X | 2.053 |
45. | Aniket P. Sarkate, Deepak K. Lokwani, Sushilkumar S. Bahekar, Devanand B. Shinde, | Synthesis and docking studies of 2-(nitrooxy) ethyl-4-(2-(substitutedphenyl)-4-(substitutedphenyl)-1h-imidazol-1-yl)benzoate as anti-inflammatory, analgesic and nitric oxide releasing agents, | Int. J. Pharm. Pharmaceut. Sci.
| 2015 | 0975-1491 | 0 |
46. | Deepak Lokwani, Rajaram Azad, Aniket Sarkate, Pallu Reddanna, Devanand Shinde, | Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors, | Bioorg. Med. Chem.
| 2015 | 0968-0896 | 3.073 |
47. | Jaiprakash N. Sangshetti, Deepak K. Lokwani, Rashmi S. Chouthe, Bhuvan Raval, Firoz A. Kalam Khan, Devanand B. Shinde | Green synthesis and biological evaluation of some new benzothiazolo [2,3-b] quinazolin-1-ones as anticancer agents, | Med. Chem. Res.
| 2014 | 1554-8120 | 1.783 |
48. | Santosh Mokale, Deepak Lokwani, Devanand Shinde | Synthesis, in-vitro reverse transcriptase inhibitory activity and docking study of some new imidazol-5-one analogs. | Med. Chem. Res.
| 2014 | 1554-8120 | 1.783 |
49. | Deepak Lokwani, Santosh Mokale, Devanand Shinde | 3D QSAR studies based in-silico screening of 4,5,6-triphenyl-1,2,3,4-tetrahydropyrimidine analogs for anti- inflammatory activity | Eur. J. Med. Chem.
| 2014 | 0223-5234 | 5.572 |
50. | Deepak K. Lokwani, Aniket P. Sarkate, Devanand B. Shinde | 3D-QSAR and docking studies of benzoyl urea derivatives as tubulin-binding agents for antiproliferative activity | Med. Chem. Res.
| 2013 | 1554-8120 | 1.783 |
51. | Deepak Lokwani, Reecha Shah, Santosh Mokale, Padma Shastry, Devanand Shinde | Development of energetic pharmacophore for the designing of 1,2,3,4-tetrahydropyrimidine derivatives as selective cyclooxygenase-2 inhibitors | J. Comput. Aided Mol. Des.
| 2012 | 1573-4951 | 2.546 |
52. | Santosh N. Mokale, Deepak Lokwani, Devanand B. Shinde | Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors | Bioorg. Med. Chem.
| 2012 | 0968-0896 | 3.073 |
53. | Jaiprakash N. Sangshetti, Deepak K. Lokwani, Aniket P. Sarkate, Devanand B. Shinde | Synthesis, Antifungal Activity, and Docking Study of Some New 1,2,4-triazole Analogs | Chem. Biol. Drug. Design
| 2011 | 1747-0285 | 2.548 |
54. | Aniket P. Sarkate, Deepak K. Lokwani, Ajit A. Patil, Shashikant V. Bhandari and Kailash G. Bothara | Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenicity and nitric oxide-releasing studies of novel ibuprofen analogs as nonulcerogenic derivatives | Med. Chem. Res
| 2011 | 1554-8120 | 1.783 |
55. | Deepak Lokwani, Shashikant Bhandari, Radha Pujari, Padma Shastri, Ganesh shelke, Vidya Pawar | Use of Quantitative Structure-Activity Relationship (QSAR) and ADMET prediction studies as screening methods for design of benzyl urea derivatives for anti-cancer activity | J. Enz. Inhibit. Med. Chem.
| 2011 | 1475-6374 | 4.673 |
56. | Vidya S. Pawar, Deepak K. Lokwani, Shashikant V. Bhandari, Kailash G. Bothara, Trupti S. Chitre, Titiksh L. Devale, NileemaS. Modhave, Jignesh K. Parikh | Design, docking study and ADME prediction of Isatin derivatives as anti-HIV agents | Med. Chem. Res.
| 2011 | 1554-8120 | 1.783 |
57. | Vidya Pawar, Deepak Lokwani, Shashikant Bhandari, Debashis Mitra, Sudeep Sabde, Kailash Bothara, Ashwini Madgulkar | Design of potential reverse transcriptase inhibitor containing Isatin nucleus using molecular modeling studies | Bioorg. Med. Chem.
| 2010 | 0968-0896 | 3.073 |
58. | Shashikant V. Bhandari, Jignesh K. Parikh, Kailash G. Bothara, Trupti S. Chitre, Deepak K. Lokwani, Titiksh L. Devale, Nileema S. Modhave, Vidya S. Pawar, Santosh Panda | Design, synthesis, and evaluation of anti-inflammatory, analgesic, ulcerogenicity, and nitric oxide releasing studies of novel indomethacin analogs as non-ulcerogenic derivatives | J. Enz. Inhibit. Med. Chem.
| 2010 | 1475-6374 | 4.673 |
59. | Shashikant Bhandari, Kailash Bothara, Vidya Pawar, Deepak Lokwani, Titiksh Devale | Design of New Chemicals Entities as Selective COX–2 Inhibitors using Structure Optimization by Molecular Modeling Studies | Int. Elect. J. Mol. Design.
| 2010 | – | 0 |
60. | Shashikant V. Bhandari, Sudarshan C. Dangre, Kailash G. Bothara, Ajit A. Patil, Aniket P. Sarkate, Deepak K. Lokwani, Suraj T. Gore, Bhavana J. Deshmane, Vyankatesh T. Raparti, Chetan V. Khachane | Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs | Eur. J. Med. Chem.
| 2009 | 0223-5234 | 5.572 |
61. | Parmeshwar R. Devhare, Shirish Jain, Gajanan Sonwane, Vijay Borkar 1 and Rushikesh Diwre | Identification and optimization of binding site for an active Metabolite of Clopidogrel, Prasugrel and Ticlopidine on receptor P2y12 | Indian Journal of Pharmaceutical Science and Research
| 2021
| 0975-8232 |
|
62. | Suyog Cheke,Satish Shelke,Rushikesh Diware,Shirish Jain | Quality By Design A Quality Enhancement Tool For Pharmaceutical Product | Word Journal of Pharmacy and Pharmaceutical Sciences | 2021
| 2278-4357
|
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63. | Miss.Poonam Chaure,Satish Shelke,Dr.Shirish Jain | A Review on Estimation of Etrocoxib and Paracetamol in Pharamceutical Doasge Form | International Journal of Trend in Scientific Research and Development (IJTRSRD)
| 2021
| 2456-6470
|
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64. | Miss.Shubhangi P.Nawarkhele, Satish Shelke,Pallvi Waghmare | A review on Estimation of Metformin Hydrochloride and Vildagliptin in Pharmaceutical Dosage Form | International Journal of Trend in Scientific Research and Development (IJTRSRD | 2021 | 2456-6470 |
|
65. | Archan Chavan,Satish Shelke,Pavan Jadhav | COVID 19: Outbreak, Structure and Current Therapeutic Strategies. | International Journal of Pharmacy & Life Sciences . Jul2020, Vol. 11 Issue 7 | 2020 | 0976-7126 |
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66. | Amol Ghodke, Satish Shelke, Shirish jain, Sandeep Ambore | Investigation, formulation and evaluation of antidiabetic tablet of puncagrnatum peel | International Journal And Biological Sciences | 2018 | 2321-3272 |
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67. | Umesh Bochre,Satish Shelke,Shirish Jain | formulation and evaluation of sustained release matrix tablet of Glipizide by using combination of natural and synthetic polymer | Journal of Pharma Research | 2018 | 2319-5622 |
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68. | Satish Shelke M.A.Channawar, A.P.Dewani, A.V.Chandewar | Validated RP-HPLC method for simultaneous estimation of Cefixime and Ornidazole in tablet dosage forms. | International Journal of Universal Pharmacy and Life Sciences | 2012 | 2249- 6793 |
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Grants Fetched
Dr. Vijay Borkar
- Received BCUD grant for major project from Savitribai Phule Pune University, Pune for the year 2013; Amount sanctioned: 2.4 lakh; Present status: completed.
Dr. Deepak Lokwani
- Received ICMR grant for Senior Research Fellowship project for the year 2014; Amount sanctioned: 6.15 lakh; Present status: completed.
IPR
Name of Inventor / Applicant | Title of Patent | Status (File/ Published / Grant) | Patent No | Date (File/ Published / Grant) |
Nil | Nil | Nil | Nil | Nil |
Year 2018-19
Sr. No. | Faculty name | Student name | Title of project |
1. | Dr. Deepak Lokwani | Prashant G. Rajput | Development And Validation of HPLC Method For Estimation Of Lymecycline In Bulk And Capsule Dosage Form |
Year 2019-20
Sr. No. | Faculty name | Student name | Title of project |
1. | Dr. Deepak Lokwani | Sandeep Pawara | Structure based Drug Design, synthesis and Pharmacological Evalution of GluN1-1a/Glu2B NMDAR Antagonists as antiseizure agents |
Year 2020-21
Sr. No. | Name of Guide | Name of Candidate | Title of Dissertation |
1 | Dr. Gajanan Sonwane | Mr. Pavan Sanjay Jadhao | The Study of Analytical Equivalence Of Generic And Branded-Name Drug |
2 | Dr. Vijay S. Borkar | Miss. Archana Bhagvan Chavhan | Analytical Method Development And Validation Of Lopinavir And Ritonavir In Bulk And Pharmaceutical Dosage Form |
3 | Prof. S.P. Shelke | Miss. Shubhangi P. Nawarkhele | Development And Validation Of Stability Indicating Rp-Hplc Method For Simultaneous Estimation Of Metformin Hydrochloride And Vildagliptin In Bulk And Pharmaceutical Dosage Form |
4 | Dr. Vijay S. Borkar | Mr. Jaydatt Bhagwanrao Mitkar | Forced Degradation Study Of Dolutegravir And Lamivudine In Formulation |
| Dr. Darshan R. Telange | Mr. Swapnil Rohidas Jadhao | Development And Characterization Of Phospholipid Complex Loaded Matrix Film For Improve Transdermal Permeation Of Ferulic Acid |
6 | Dr. Vijay S. Borkar | Mr. Vishal Gajanan Murkute | Phytochemical Study And The Isolation Of Some Phytoconstituents From Cassia Fistula |
7 | Dr. Vijay S. Borkar | Miss. Pallavi Balaji Waghmare | Analytical Method Development And Validation Of Anti Anginal Drug |
8 | Dr. Vijay S. Borkar | Mr. Akshay Ratan Kale | Rp-Hplc Method Validation For The Determination Of Levetiracetam In Bulk And Marketed Formulation |
9 | Prof. S.P.Shelke | Miss. Poonam H. Chaure | Development And Validation Of Analytical Method For The Estimation Of Nsaid Drugs |
10 | Prof. S.P.Shelke | Mr. Ankush T. Mane | Formulation And Process Validation Of Oral Solid Dosage Form Of Prothionamide Tablet |
AWARDS AND ACHIEVEMENTS
Dr. Vijay Borkar
- Resource person for person at AICTE sponsored STTP for delivering session on “How to ensure effective mentoring” at Rajarshi Shahu College of Pharmacy, Bulldana (MS) during 27th July 2021 to 1st August 2021.
- Resource person for person at Induction Program for delivering session on “Pharmacy Profession and Pharmaceutical Chemistry ” at Sant Gajanan Maharaj College of Pharmacy, Bulldana (MS) on 1st February 2021.
- Resource person for person for delivering session on “Stereochemistry ” at Dr VV Patil foundations College of Pharmacy, A. Nagar (MS) on 18th August 2020.
- Resource person for person for delivering session on “Stereochemistry and its perspectives of structural alterations” at Vellar College of Pharmacy, Erode, TN, on 25th August 2020.
Dr. Deepak Lokwani
- Received Letter of Appreciation and coordination for contribution in conducting Zonal Center Program on Drug Discovery, Designing and Development by E-cell IIT Kharagpur in associate with Makeintern.com, Jan. 2019.
- Selection of An Image from Research Paper as a Cover page of Journal of Heterocyclic Chemistry (Wiley Interscience) (DOI: 10.1002/jhet.3013), 2017.
- Award of Senior Research Fellowship From ICMR on the Research Project entitlted “Structure based Screening of 1,2-Dihydropyrimidine annalogues to design potential safer Anti-inflammatory agents, 2014.
- Received National Prize for Short Film made for CSIR-OSDD-VP short Video Competition on Topic “The Need of New Drugs for Tuberculosis”, 2014.
- Received Second Prize for Poster Presentation in National conference on Computational Biology and Chemistry held at School of Bio Sciences and Technology, VIT University, 2012.
- Received Outstanding Publication Award by vLife Sciences, Pune in the field of Computer Aided Drug and Molecular Design, 2011.
- Qualified GATE 2007 conducted by IIT, Kanpur with 08 Percentile (AIR 1079, GATE Score 413), 2007.
Mr. Rushikesh Diware
- Qualified GPAT exam in 2013 and 2016
- Analyst of the month By Lupin limited Nagpur in March 2018
- Invited as a speaker at Dr. Vithalrao Vikhe Patil Foundation’s , College of Ahmednagar for a guest lecture on ‘GPAT preparation on Drug acting on Central Nervous system’
DEPARTMENT ACTIVITIES
Sr. No. | Topic of workshop/conference/webinar | Name of speaker, designation and organization | Coordinator/Convenor/Co-convenor | Date | Platform used |
1. | Hands on HPLC | Mr. Ankush Kalwaghe, Senior Research Associate, Sun Pharma PVT., LTD, Wadodara, Gujrat. | Mr. Satish Shelke | 12th Feb 2018 | Physical |
2. | Applications of miniatures in micro-synthesis and micro analysis | Dr. Vijay Borkar, Associate Professor, RSCP, Buldana. | Dr. Gajanan Sonwane | 22nd Dec 2018 | Physical |
3. | HPLC trouble shooting and scientific article writing | Dr. V. K. Mourya, Principal, Gov College of Pharmacy, Aurangabad. Dr. J. N. Sangshetti, Associate Professor, YB Chavan College of Pharmacy, Aurangabad. Dr. U. A. Deokate, Associate Professor, Gov College of Pharmacy, Aurangabad. | Dr. Vijay Borkar Dr. Gajanan Sonwane Mr. S. L. Khan | 23rd Nov 2019 | Physical |
FACILITIES
List of Major Equipment
Sr. No. | Name of Equipment | Sr. No. | Name of Equipment |
1. | FTIR | 2. | HPLC |
3. | UV spectrophotometer | 4. | pH meter, |
5. | Nephelometer | 6. | Conductivity meter |
7. | Potentiometer | 8. | Colourimeter |
9. | Analytical balance | 10. | Sonicator |
11. | Fluorimeter | 12. | Autoanalyzer |
13. | Microwave oven | 14. | Muffle furnance |
15. | Hot air Oven | 16. | Abbe’s Refractometer |
17. | Flame Photometer | 18. | Incubator |
Facilities
